ORF Genetics – ISOkine® PREMIUM Growth Factors & Cytokines for your Next-Generation Cell & Gene Therapies

ORF Genetics is an Iceland-based plant biotech company and a pioneer specialized in the production of high-quality recombinant proteins using a proprietary barley seed recombinant protein expression platform.

Our flagship ISOkine® PREMIUM Growth Factors and Cytokines product range delivers a portfolio of animal-component-free (ACF), Endotoxin-Free, recombinant human growth factors and cytokines designed for demanding applications in regenerative medicine, advanced therapies, and cell culture. In addition, we offer expert support to help you qualify our products as ancillary materials.

ORF Genetics grows the barley in its own high-tech, eco-friendly greenhouse, located in a black lava field on the Reykjanes Peninsula, using Iceland’s rich, geothermal, renewable energy resources. We have been committed to supporting cell and gene therapy development from discovery to clinical application for over 20 years. ORF Genetics is an ISO 9001-2025 certified company.

Learn more about our products and promotional offers at https://www.orfgenetics.com/product/isokine

Why ISOkine® PREMIUM GF&C for Cell & Gene Therapy?

• Animal-component-free: Eliminates risk of contamination from animal components as well as inflamation-inducing components from bacteria, ensuring a safer, fully defined cell culture environment.

• Endotoxin-Free certification surpass strict pharmacopeia limits Our ISOkine PREMIUM GF&C are intended for translational or GMP use and meet the most stringent endotoxin specifications in regulatory guidelines: USP <85>, Ph. Eur., FDA/EMA, set as endotoxin limits (e.g., <0.25 EU/mL for many parenterals). Our products deliver 100% of the time undetectable endotoxin presence.

  • What is the Biological Impact of the presence of residual levels of endotoxins:

  • · Strong immune activation

o Endotoxins trigger TLR4 signaling → induce cytokine release, inflammation, and apoptosis.

o Even trace contamination can drastically alter gene expression and signaling in sensitive cultures.

· Stem cell sensitivity

o Pluripotent and progenitor cells are particularly vulnerable: endotoxins can alter differentiation pathwaysand compromise reproducibility in developmental studies or therapy manufacturing.

· Cell death and reduced viability

o High endotoxin levels can cause cell stress, reduced proliferation, or apoptosis.

o Leads to inconsistent culture outcomes and wasted experiments.

• Batch-to-batch consistency: Stable seed production system guarantees reproducible quality — critical for regulated therapy workflows.

• Defined, GMP-compatible quality: Recombinant proteins with controlled specifications to support translational and clinical manufacturing.

• Sustainability advantage: Barley seed platform offers a scalable, renewable, and environmentally friendly production process.