Professor Brian Bigger is Chair of Advanced Therapeutics at the University of Edinburgh, and Honorary Professor at the University of Manchester, UK.

The Bigger lab develops lentiviral ex vivo and AAV gene therapies for childhood dementias with two clinical trials underway in Manchester, and was the first to show the role of the inflammasome in neurodegeneration in lysosomal diseases. Brian was a co-founder of Orchard Therapeutics and past Chairman of the European Study Group for Lysosomal Diseases.